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Quantitative Multi-Modal Optical Coherence Photoacoustic ...
[Submitted on 17 Jun 2026] · 2026-06-18 · via math updates on arXiv.org

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Abstract:We present a novel multi-modal optical coherence photoacoustic elastography (OCPE) framework, which combines two imaging modalities, optical coherence tomography (OCT) and photoacoustic tomography (PAT), to enable complementary absorption-scattering measurements for the extraction of quantitative tissue features via quasi-static elastography. For this, we develop a sophisticated hybrid inversion algorithm for merging the complementary information layers contained in both OCT and PAT-based elastography measurements, and perform systematic evaluations to assess the impact of hybrid elastography data on strain and stiffness reconstructions. Studies on a silicone elastomer phantom demonstrate that the combined OCT-PAT approach outperforms single-modality OCT elastography and PAT elastography, yielding higher strain signal-to-noise ratio and improved stiffness estimates. These results establish the advantage of multi-modal complementary imaging and data merging for accurate, high-resolution elastographic strain and stiffness mapping in both scattering and absorbing materials.

Submission history

From: Ekaterina Sherina [view email]
[v1] Wed, 17 Jun 2026 12:12:11 UTC (17,268 KB)