Johnson graph are a family of graphs that play an important role in the theory of constant-weight codes, extremal combinatorics, and combinatorial geometry. We study signed analogues of classical Johnson graphs, denoted by $J_\pm(n,k)$, whose vertices are vectors of the form $\pm e_{i_1}\pm\cdots\pm e_{i_k}$, where two vertices are adjacent whenever their dot product equals $k-1$. We are particularly interested in maximum independent sets in the case $k=4$. An example of such an independent set in $J_\pm(n,4)$, which we call \emph{classical}, is obtained by lifting an arbitrary optimal $(n,4,4)$-code. Such independent sets naturally define kissing arrangements in ${\mathbb R}^n$. We develop an algorithm that is practical for computing all maximum independent sets in $J_\pm(n,4)$ up to signed permutations for $n\le 12$, $n\ne 11$. In addition to obtaining complete lists, we provide structural characterizations of all types of maximum independent sets in these dimensions, excluding $n=5$ and $n=11$. Our most striking results concern the case $n=12$. We identify $1579$ non-isomorphic maximum independent sets in $J_\pm(12,4)$, all corresponding to non-isometric kissing arrangements of size $840$ in ${\mathbb R}^{12}$. Structurally, $1575$ of these independent sets arise from three different constructions, the rest are liftings of one of four $(12,4,4)$-codes. To our knowledge, this is the first dimension in which such a large diversity of potentially optimal kissing arrangements has been observed. Beyond this finite range, we prove that for $n\equiv 2$ or $4 \pmod 6$, every maximum independent set arises from a Steiner quadruple system. We also obtain a characterization of the so-called \emph{nontrivially self-compatible} codes, namely optimal $(n,4,4)$-codes from which non-classical maximum independent sets can be constructed.