Abstract:Change-plane regression represents treatment effect heterogeneity through an interpretable rule that assigns patients to two groups according to whether a linear score of baseline covariates crosses a threshold. Although easy to communicate, likelihood-based inference for the hard threshold is nonregular, invalidating standard large-sample approximations. We develop a Bayesian framework that replaces the sharp indicator with a smooth probit gate at a declared smoothing scale and treats the smoothed subgroup rule as the reported estimand. At a fixed smoothing scale, the posterior satisfies a misspecified Bernstein--von Mises theorem centered at the smoothed rule. Under a vanishing smoothing schedule, the posterior learns the boundary faster than the parametric rate, while within an explicit schedule window the regression block and treatment-effect contrast satisfy a Bernstein--von Mises theorem centered at the hard-threshold values with known-subgroup oracle efficiency. Thus, effect inference pays no first-order price for regularization. A decision-theoretic reporting protocol with consistency guarantees separates evidence of heterogeneity from reporting a boundary. Computation uses latent-variable augmentation, a great-circle elliptical slice sampler, and a normalized horseshoe prior. Simulations and an application to the PREMIER trial illustrate the method.
From: Yuki Ohnishi [view email]
[v1]
Sun, 26 Apr 2026 19:40:53 UTC (1,465 KB)
[v2]
Tue, 21 Jul 2026 15:55:17 UTC (1,328 KB)
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