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On Stability and Decomposition of Sample Quantiles under Heavy-Tailed Distributions Improved Baselines with Representation Autoencoders Symmetry-Compatible Principle for Optimizer Design: Embeddings, LM Heads, SwiGLU MLPs, and MoE Routers Feature Learning in Linear-Width Two-Layer Networks: Two vs. One Step of Gradient Descent Calibeating for general proper losses: A Bregman divergence approach Dimension-Free Convergence of Discrete Diffusion Models: Adjoint Equations Induce the Right Space Sample-efficient inductive matrix completion with noise and inexact side-information Multi-task Linear Regression without Eigenvalue Lower Bounds: Adaptivity, Robustness, and Safety XAI and Statistical Analysis for Reliable Intrusion Detection in the UAVIDS-2025 Dataset: From Tree to Hybrid and Tabular DNN Ensembles Reasoning Models Don't Just Think Longer, They Move Differently TabPFN-3: Technical Report Reframing preprocessing selection as model-internal calibration in near-infrared spectroscopy: A large-scale benchmark of operator-adaptive PLS and Ridge models Towards a holistic understanding of Selection Bias for Causal Effect Identification Adaptive Kernel Density Estimation with Pre-training Coreset-Induced Conditional Velocity Flow Matching RISED: A Pre-Deployment Evaluation Framework for High-Stakes AI Decision-Support Systems, with Application to Healthcare ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks Yield Curves Dynamics Using Variational Autoencoders Under No-arbitrage Model-based Bootstrap of Controlled Markov Chains Online Learning-to-Defer with Varying Experts Self-Supervised Laplace Approximation for Bayesian Uncertainty Quantification Keeping Score: Efficiency Improvements in Neural Likelihood Surrogate Training via Score-Augmented Loss Functions One-Step Generative Modeling via Wasserstein Gradient Flows Exact Stiefel Optimization for Probabilistic PLS: Closed-Form Updates, Error Bounds, and Calibrated Uncertainty A Composite Activation Function for Learning Stable Binary Representations Adaptive Calibration in Non-Stationary Environments Real vs. Semi-Simulated: Rethinking Evaluation for Treatment Effect Estimation Federated Language Models Under Bandwidth Budgets: Distillation Rates and Conformal Coverage On Variance Reduction in Learning Mean Flows When Attention Beats Fourier: Multi-Scale Transformers for PDE Solving on Irregular Domains A Refined Generalization Analysis for Extreme Multi-class Supervised Contrastive Representation Learning Ensemble Distributionally Robust Bayesian Optimisation The Proxy Presumption: From Semantic Embeddings to Valid Social Measures Modulated learning for private and distributed regression with just a single sample per client device Query-efficient model evaluation using cached responses Order-Agnostic Autoregressive Modelling with Missing Data Grokking or Glitching? 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MEC-Cox: Machine-Learning-Assisted Generalized Entropy Calibration for ATT Marginal Hazard-Ratio Estimation
Se Yoon Lee, Yonghyun Kwon, Jae Kwang Kim · 2026-06-07 · via stat updates on arXiv.org

Externally controlled survival trials are increasingly used when concurrent randomized controls are infeasible, particularly in oncology and rare-disease settings with time-to-event endpoints. We target an average-treatment-effect-on-the-treated (ATT)-type marginal hazard-ratio estimand, comparing treatment with counterfactual control in the treated trial population, and estimate it using inverse-probability-weighted (IPW) Cox regression. Valid inference is challenging because IPW Cox regression depends on the weights through both event contributions and risk-set averages, making flexible machine-learning nuisance estimation difficult to incorporate directly. Building on machine-learning-assisted generalized entropy calibration (MEC) by Lee and Kim (2026), we propose MEC-Cox for ATT-weighted IPW Cox regression. The method begins with normalized source-propensity-score odds weights for external controls and then applies Bregman calibration to balance cross-fitted prognostic summaries between external controls and treated trial patients. The calibration basis may include control-survival predictions, Cox linear predictors, penalized-survival-model predictions, or other prognostic-score summaries. MEC-updated weights therefore play a dual role as source-transport and prognostic-score balancing weights. We establish consistency, characterize a calibration-induced efficiency gain, and develop a stacked sandwich variance estimator. Simulations show that MEC-Cox can reduce bias, increase efficiency, and improve coverage through flexible machine-learning-assisted adjustment.