Abstract:Post-marketing pharmacovigilance relies on statistical signal detection methods to identify potential adverse drug reactions. The Weibull shape parameter (WSP) test concept exploits temporal information (electronic health records) to assess the hazard of an adverse event over time after drug initiation. A statistically significant deviation from constancy results in a signal. The WSP framework comprises a family of tests that differ with respect to the estimation approach (frequentist or Bayesian), the chosen time-to-event distribution (Weibull, double Weibull, power generalized Weibull) for hazard modeling, and test specification parameters. To facilitate practical application and encourage consideration of the WSP signal detection test in future research, we developed the R package WSPsignal. The package consolidates all functionalities required for WSP testing into a unified, open-source interface. It enables practitioners and researchers to apply default test specifications or perform simulation-based tuning to identify the optimal test for a given data scenario. We illustrate the package functionalities in two examples to follow along. In a large-sample setting (ca. 20 000 observations), a frequentist WSP test is considered. In a small-sample setting (ca. 1 000 observations), a Bayesian WSP test is chosen. The additional test specifications are optimized through simulation-based tuning.
From: Julia Dyck [view email]
[v1]
Wed, 17 Jun 2026 08:25:49 UTC (557 KB)
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