Backpropagation is the default learning rule for artificial neural networks and is often treated as the settled approach whenever differentiability is available. In this work, we revisit this convention through a theoretical lens of sample efficiency. We introduce a unified vectorized feedback framework for loss-based and reward-based learning on computational graphs, in which synthetic gradients emerge as a natural alternative to backpropagation. We characterize the conditions under which synthetic gradients can achieve a lower gradient-estimation mean squared error than backpropagation. We construct examples illustrating that this sample efficiency advantage can be arbitrarily large. Experiments on contextual bandits and reinforcement learning tasks demonstrate the potential of our theoretical findings.