We study Euler characteristics of scaled toric varieties arising from second hypersimplices. In algebraic statistics, these are closely connected to maximum likelihood (ML) degrees of toric models. We establish a correspondence between delta-matroids and the non-vanishing factors of the principal $A$-determinant, providing an explicit connection between delta-matroid theory and algebraic statistics. Using this framework, we show that a conjectured minimum ML degree is realizable by a suitable embedding of the variety. Furthermore, for second hypersimplices up to order six, we prove that this value is minimal among all embeddings, as conjectured by Clarke et al. (2024).