Abstract:Longitudinal data collected in clinical trials are almost always incomplete due to some of the participants dropping out from the study during the planned follow-up. A common strategy to handle nonresponse expresses missingness in terms of a dropout process, which is jointly analysed with the outcome process to facilitate the formulation of the missingness assumptions. However, when the outcome is multivariate, the identification of the dropout process becomes problematic, especially when individuals have different dropout times for each type of response, and sensitivity analysis is difficult. The modelling task may be also be complicated by data complexities (e.g. skewness and spikes) which are difficult to capture through standard parametric methods. An example of this analysis framework occurs in trial-based economic evaluations, where a longitudinal bivariate response, formed by suitably-defined measures of effectiveness and costs, is analysed to inform policymakers about the cost-effectiveness of alternative interventions. We present a novel Bayesian nonparametric approach to handle a missing bivariate longitudinal outcome by jointly modelling the dropout process associated with each type of response while also taking into account the complexities of the data. We specify a flexible nonparametric model for the observed data and partially identify the distribution of the missing data with identifying restrictions conditional on the dropout indicators and sensitivity parameters. We explore alternative nonignorable scenarios through different priors for the sensitivity parameters. Our approach is motivated by, and applied to, data from a trial assessing the cost-effectiveness of a new treatment for intellectual disability and challenging behaviour.
From: Andrea Gabrio [view email]
[v1]
Wed, 24 Jun 2026 12:18:07 UTC (257 KB)
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