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Shallow ReLU$^s$ Networks in $L^p$-Type and Sobolev Spaces: Approximation and Path-Norm Controlled Generalization On Stability and Decomposition of Sample Quantiles under Heavy-Tailed Distributions Improved Baselines with Representation Autoencoders Symmetry-Compatible Principle for Optimizer Design: Embeddings, LM Heads, SwiGLU MLPs, and MoE Routers Feature Learning in Linear-Width Two-Layer Networks: Two vs. One Step of Gradient Descent Calibeating for general proper losses: A Bregman divergence approach Dimension-Free Convergence of Discrete Diffusion Models: Adjoint Equations Induce the Right Space Sample-efficient inductive matrix completion with noise and inexact side-information Multi-task Linear Regression without Eigenvalue Lower Bounds: Adaptivity, Robustness, and Safety XAI and Statistical Analysis for Reliable Intrusion Detection in the UAVIDS-2025 Dataset: From Tree to Hybrid and Tabular DNN Ensembles Reasoning Models Don't Just Think Longer, They Move Differently TabPFN-3: Technical Report Reframing preprocessing selection as model-internal calibration in near-infrared spectroscopy: A large-scale benchmark of operator-adaptive PLS and Ridge models Towards a holistic understanding of Selection Bias for Causal Effect Identification Adaptive Kernel Density Estimation with Pre-training Coreset-Induced Conditional Velocity Flow Matching RISED: A Pre-Deployment Evaluation Framework for High-Stakes AI Decision-Support Systems, with Application to Healthcare ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks Yield Curves Dynamics Using Variational Autoencoders Under No-arbitrage Model-based Bootstrap of Controlled Markov Chains Online Learning-to-Defer with Varying Experts Self-Supervised Laplace Approximation for Bayesian Uncertainty Quantification Keeping Score: Efficiency Improvements in Neural Likelihood Surrogate Training via Score-Augmented Loss Functions One-Step Generative Modeling via Wasserstein Gradient Flows Exact Stiefel Optimization for Probabilistic PLS: Closed-Form Updates, Error Bounds, and Calibrated Uncertainty A Composite Activation Function for Learning Stable Binary Representations Adaptive Calibration in Non-Stationary Environments Real vs. Semi-Simulated: Rethinking Evaluation for Treatment Effect Estimation Federated Language Models Under Bandwidth Budgets: Distillation Rates and Conformal Coverage On Variance Reduction in Learning Mean Flows When Attention Beats Fourier: Multi-Scale Transformers for PDE Solving on Irregular Domains A Refined Generalization Analysis for Extreme Multi-class Supervised Contrastive Representation Learning Ensemble Distributionally Robust Bayesian Optimisation The Proxy Presumption: From Semantic Embeddings to Valid Social Measures Modulated learning for private and distributed regression with just a single sample per client device Query-efficient model evaluation using cached responses Order-Agnostic Autoregressive Modelling with Missing Data Grokking or Glitching? 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Binary Gaussian Copula Synthesis: an LLM-powered data augmentation framework for early dialysis prediction in chronic kidney disease
Hamed Khosravi, Milad Khanchi, Mobina Noori, Srinjoy Das, Abdull · 2024-03-02 · via stat updates on arXiv.org

Only a small fraction of patients with chronic kidney disease (CKD) progress to dialysis, creating severe class imbalance that limits the performance of machine learning models for early dialysis prediction. This challenge is compounded by the binary structure of electronic health record (EHR) data, for which most existing augmentation methods were not designed. We propose Binary Gaussian Copula Synthesis (BGCS), a two-stage data augmentation method tailored to binary clinical data. BGCS first generates synthetic minority-class samples using a Gaussian copula framework that explicitly models pairwise dependencies among binary features, then applies a fine-tuned GPT-2 classifier to filter out clinically implausible samples before training. We evaluated BGCS on a real-world EHR dataset of 15,169 patients with CKD from West Virginia collected between 2008 and 2022, benchmarking it against SMOTE, CTGAN, and standard Gaussian Copula across four machine learning classifiers over 25 independent runs. BGCS consistently outperformed all comparison methods, achieving the highest minority-class recall for 90-day dialysis prediction, with median values ranging from 0.78 to 0.87 across classifiers, and the strongest distributional fidelity to real data, with a mean p-value of 0.68 across features. The best-performing BGCS-augmented model was integrated into an interpretable decision tree-based clinical decision support system for dialysis risk stratification, with electrolyte imbalances, cardiovascular comorbidities, and renal monitoring indicators emerging as the most influential predictive features. These findings suggest that augmentation methods designed for the structural properties of binary EHR data can meaningfully improve early dialysis risk prediction and support the development of interpretable clinical decision-support tools for CKD care.