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Abstract:College students commonly report insufficient sleep and poor sleep quality, with ~30% meeting insomnia criteria, posing significant threats to their physical growth, cognitive development, and overall well-being, as well as imposing a substantial economic burden on society [1]. The hyperarousal model of insomnia [2] emphasizes that hyperarousal across cognitive, emotional, and physiological domains mutually reinforces one another. Neuroimaging studies have further identified prefrontal hypoactivity as a key neural substrate underlying these dysfunctional cognitions and elevated arousal, reflecting a failure of top-down modulatory control over both limbic reactivity [3] and brainstem arousal nuclei [4]. Moreover, transcranial photobiomodulation (tPBM) therapy targeting the prefrontal cortex has demonstrated therapeutic efficacy across neuropsychiatric disorders with insomnia comorbidities [5,6], providing preliminary support for its application in insomnia. However, the neuro mechanisms underlying tPBM's therapeutic effects on insomnia remain to be elucidated.
From: Jiangshan He [view email]
[v1]
Tue, 23 Jun 2026 15:03:24 UTC (396 KB)
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