Seamless operation of mobile robots in challenging environments requires low-latency local motion estimation (e.g., dynamic maneuvers) and accurate global localization (e.g., wayfinding). While most existing sensor-fusion approaches are designed for specific scenarios, this work introduces a flexible open-source solution for task- and setup-agnostic multimodal sensor fusion that is distinguished by its generality and usability. Holistic Fusion formulates sensor fusion as a combined estimation problem of i) the local and global robot state and ii) a (theoretically unlimited) number of dynamic context variables, including automatic alignment of reference frames; this formulation fits countless real-world applications without any conceptual modifications. The proposed factor-graph solution enables the direct fusion of an arbitrary number of absolute, local, and landmark measurements expressed with respect to different reference frames by explicitly including them as states in the optimization and modeling their evolution as random walks. Moreover, local smoothness and consistency receive particular attention to prevent jumps in the robot state belief. HF enables low-latency and smooth online state estimation on typical robot hardware while simultaneously providing low-drift global localization at the IMU measurement rate. The efficacy of this released framework is demonstrated in five real-world scenarios on three robotic platforms, each with distinct task requirements.