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ULF-Synth: Physics-Guided Ultra-Low-Field MRI Enhancement for Pediatric Neuroimaging
Toufiq Musah · 2026-05-26 · via cs updates on arXiv.org

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Abstract:Ultra-low-field (ULF) MRI offers portable and accessible neuroimaging but suffers from reduced signal-to-noise ratio and limited spatial resolution compared to high-field (HF) systems. Acquiring paired ULF-HF data for supervised enhancement is often difficult, particularly in resource-limited settings. We introduce ULF-Synth, a framework that combines: (i) acquisition-based synthesis of realistic ULF images from HF volumes to create large-scale paired training data, (ii) a spatial-frequency domain objective that prioritizes recovery of high-frequency anatomical detail. This formulation is architecture-agnostic, consistently improving structural similarity and perceptual fidelity across encoder-decoder, adversarial, and diffusion-based translation models. When trained exclusively on synthetic data, the resulting models generalize effectively to real 64mT ULF acquisitions, improving downstream multiclass brain segmentation and achieving higher radiologist preference and diagnostic acceptability in a blinded reader study. These findings demonstrate that synthetic paired supervision provides a practical and scalable pathway for enhancing ULF MRI without requiring real paired acquisitions. Code, Models and Dataset: this https URL
Comments: 10 pages, 2 figures, 3 tables
Subjects: Computer Vision and Pattern Recognition (cs.CV)
Cite as: arXiv:2605.24625 [cs.CV]
  (or arXiv:2605.24625v1 [cs.CV] for this version)
  https://doi.org/10.48550/arXiv.2605.24625

arXiv-issued DOI via DataCite (pending registration)

Submission history

From: Toufiq Musah [view email]
[v1] Sat, 23 May 2026 15:33:44 UTC (27,455 KB)