Robust 6D object pose estimation in cluttered or occluded conditions using monocular RGB images remains a challenging task. One reason is that current pose estimation networks struggle to extract discriminative, pose-aware features using 2D feature backbones, especially when the available RGB information is limited due to target occlusion in cluttered scenes. To mitigate this, we propose a novel pose estimation-specific pre-training strategy named Mask6D. Our approach incorporates pose-aware 2D-3D correspondence maps and visible mask maps as additional modal information, which is combined with RGB images for the reconstruction-based model pre-training. Essentially, this 2D-3D correspondence maps a transformed 3D object model to 2D pixels, reflecting the pose information of the target in camera coordinate system. Meanwhile, the integrated visible mask map can effectively guide our model to disregard cluttered background information. In addition, an object-focused pre-training loss function is designed to further facilitate our network to remove the background interference. Finally, we fine-tune our pre-trained pose prior-aware network via conventional pose training strategy to realize the reliable pose prediction. Extensive experiments verify that our method outperforms previous end-to-end pose estimation methods.