Diffusion models (DMs) have become dominant in visual generation but suffer performance drop when tested on resolutions that differ from the training scale, whether lower or higher. In fact, the key challenge in generating variable-scale images lies in the differing amounts of information across resolutions, which requires information conversion procedures to be varied for generating variable-scaled images. In this paper, we investigate the issues of three critical aspects in DMs for a unified analysis in variable-scaled generation: dilated convolution, attention mechanisms, and initial noise. Specifically, 1) dilated convolution in DMs for the higher-resolution generation loses high-frequency information. 2) Attention for variable-scaled image generation struggles to adjust the information aggregation adaptively. 3) The spatial distribution of information in the initial noise is misaligned with variable-scaled image. To solve the above problems, we propose \textbf{InfoScale}, an information-centric framework for variable-scaled image generation by effectively utilizing information from three aspects correspondingly. For information loss in 1), we introduce Progressive Frequency Compensation module to compensate for high-frequency information lost by dilated convolution in higher-resolution generation. For information aggregation inflexibility in 2), we introduce Adaptive Information Aggregation module to adaptively aggregate information in lower-resolution generation and achieve an effective balance between local and global information in higher-resolution generation. For information distribution misalignment in 3), we design Noise Adaptation module to re-distribute information in initial noise for variable-scaled generation. Our method is plug-and-play for DMs and extensive experiments demonstrate the effectiveness in variable-scaled image generation.