In one-stage multi-object detection tasks, various intersection over union (IoU)-based solutions aim at smooth and stable convergence near the targets during training. However, IoU-based losses fail to correctly update the gradient of small objects due to an extremely flat gradient. During the update of multiple objects, the learning of small objects' gradients suffers more because of insufficient gradient updates. Therefore, we propose an inter-class relational loss to efficiently update the gradient of small objects while not sacrificing the learning efficiency of other objects based on the simple fact that an object has a spatial relationship to another object (e.g., a car plate is attached to a car in a similar position). When the predicted car plate's bounding box is not within its car, a loss punishment is added to guide the learning, which is inversely proportional to the overlapped area of the car's and predicted car plate's bounding box. By leveraging the spatial relationship at the inter-class level, the loss guides small object predictions using larger objects and enhances latent information in deeper feature maps. In this paper, we present twofold contributions using license plate detection as a case study: (1) a new small vehicle multi-license plate dataset (SVMLP), featuring diverse real-world scenarios with high-quality annotations; and (2) a novel inter-class relational loss function designed to promote effective detection performance. We highlight the proposed ICR loss penalty can be easily added to existing IoU-based losses and enhance the performance. These contributions improve the standard mean Average Precision (mAP) metric, achieving gains of 10.3% and 1.6% in mAP$^{\text{test}}_{50}$ for YOLOv12-T and UAV-DETR, respectively, without any additional hyperparameter tuning. Code and dataset will be available soon.