Diffusion transformers have gained significant attention in recent years for their ability to generate high-quality images and videos, yet still suffer from a huge computational cost due to their iterative denoising process. Recently, feature caching has been introduced to accelerate diffusion transformers by caching the feature computation in previous timesteps and reusing it in the following timesteps, which leverage the temporal similarity of diffusion models while ignoring the similarity in the spatial dimension. In this paper, we introduce Cluster-Driven Feature Caching (ClusCa) as an orthogonal and complementary perspective for previous feature caching. Specifically, ClusCa performs spatial clustering on tokens in each timestep, computes only one token in each cluster and propagates their information to all the other tokens, which is able to reduce the number of tokens by over 90%. Extensive experiments on DiT, FLUX and HunyuanVideo demonstrate its effectiveness in both text-to-image and text-to-video generation. Besides, it can be directly applied to any diffusion transformer without requirements for training. For instance, ClusCa achieves 4.96x acceleration on FLUX with an ImageReward of 99.49%, surpassing the original model by 0.51%. The code is available at https://github.com/Shenyi-Z/Cache4Diffusion.