Deepfake detection remains highly challenging, particularly in cross-dataset scenarios and complex real-world settings. This challenge mainly arises because artifact patterns vary substantially across different forgery methods, whereas adapting pretrained models to such artifacts often overemphasizes forgery-specific cues and disturbs semantic representations, thereby weakening generalization. Existing approaches typically rely on full-parameter fine-tuning or auxiliary supervision to improve discrimination. However, they often struggle to model diverse forgery artifacts without compromising pretrained representations. To address these limitations, we propose FMSD, a deepfake detection framework built upon Forgery-aware Layer Masking and Multi-Artifact Subspace Decomposition. Specifically, Forgery-aware Layer Masking evaluates the bias-variance characteristics of layer-wise gradients to identify forgery-sensitive layers, thereby selectively updating them while reducing unnecessary disturbance to pretrained representations. Building upon this, Multi-Artifact Subspace Decomposition further decomposes the selected layer weights via Singular Value Decomposition (SVD) into a semantic subspace and multiple learnable artifact subspaces. These subspaces are optimized to capture heterogeneous and complementary forgery artifacts, enabling effective modeling of diverse forgery patterns while preserving pretrained semantic representations. Furthermore, orthogonality and spectral consistency constraints are imposed to regularize the artifact subspaces, reducing redundancy across them while preserving the overall spectral structure of pretrained weights.