Bridging the simulation-to-reality (sim2real) gap remains challenging as labelled real-world data is scarce. Existing diffusion-based approaches rely on unstructured prompts or statistical alignment, which do not capture the structured factors that make images look real. We introduce Ontology- Guided Diffusion (OGD), a neuro-symbolic zero-shot sim2real image translation framework that represents realism as structured knowledge. OGD decomposes realism into an ontology of interpretable traits -- such as lighting and material properties -- and encodes their relationships in a knowledge graph. From a synthetic image, OGD infers trait activations and uses a graph neural network to produce a global embedding. In parallel, a symbolic planner uses the ontology traits to compute a consistent sequence of visual edits needed to narrow the realism gap. The graph embedding conditions a pretrained instruction-guided diffusion model via cross-attention, while the planned edits are converted into a structured instruction prompt. Across benchmarks, our graph-based embeddings better distinguish real from synthetic imagery than baselines, and OGD outperforms state-of-the-art diffusion methods in sim2real image translations. Overall, OGD shows that explicitly encoding realism structure enables interpretable, data-efficient, and generalisable zero-shot sim2real transfer.