This manuscript explores multimodal alignment, translation, fusion, and transference to enhance machine understanding of complex inputs. We organize the work into five chapters, each addressing unique challenges in multimodal machine learning. Chapter 3 introduces Spatial-Reasoning Bert for translating text-based spatial relations into 2D arrangements between clip-arts. This enables effective decoding of spatial language into visual representations, paving the way for automated scene generation aligned with human spatial understanding. Chapter 4 presents a method for translating medical texts into specific 3D locations within an anatomical atlas. We introduce a loss function leveraging spatial co-occurrences of medical terms to create interpretable mappings, significantly enhancing medical text navigability. Chapter 5 tackles translating structured text into canonical facts within knowledge graphs. We develop a benchmark for linking natural language to entities and predicates, addressing ambiguities in text extraction to provide clearer, actionable insights. Chapter 6 explores multimodal fusion methods for compositional action recognition. We propose a method fusing video frames and object detection representations, improving recognition robustness and accuracy. Chapter 7 investigates multimodal knowledge transference for egocentric action recognition. We demonstrate how multimodal knowledge distillation enables RGB-only models to mimic multimodal fusion-based capabilities, reducing computational requirements while maintaining performance. These contributions advance methodologies for spatial language understanding, medical text interpretation, knowledge graph enrichment, and action recognition, enhancing computational systems' ability to process complex, multimodal inputs across diverse applications.