Small object detection is a broadly investigated research task and is commonly conceptualized as a "pipeline-style" engineering process. In the upstream, images serve as raw materials for processing in the detection pipeline, where pre-trained models are employed to generate initial feature maps. In the midstream, an assigner selects training positive and negative samples. Subsequently, these samples and features are fed into the downstream for classification and regression. Previous small object detection methods often focused on improving isolated stages of the pipeline, thereby neglecting holistic optimization and consequently constraining overall performance gains. To address this issue, we have optimized three key aspects, namely Purifying, Labeling, and Utilizing, in this pipeline, proposing a high-quality Small object detection framework termed PLUSNet. Specifically, PLUSNet comprises three sequential components: the Hierarchical Feature Purifier (HFP) for purifying upstream features, the Multiple Criteria Label Assignment (MCLA) for improving the quality of midstream training samples, and the Frequency Decoupled Head (FDHead) for more effectively exploiting information to accomplish downstream tasks. The proposed PLUS modules are readily integrable into various object detectors, thus enhancing their detection capabilities in multi-scale scenarios. Extensive experiments demonstrate the proposed PLUSNet consistently achieves significant and consistent improvements across multiple datasets for small object detection.