This paper presents the Harmonic Beltrami Signature Network (HBSN), a novel deep learning architecture for computing the Harmonic Beltrami Signature (HBS) from binary-like images. HBS is a shape representation that provides a one-to-one correspondence with 2D simply connected shapes, with invariance to translation, scaling, and rotation. By exploiting the function approximation capacity of neural networks, HBSN enables efficient extraction and utilization of shape prior information. The proposed network architecture incorporates a pre-Spatial Transformer Network (pre-STN) for shape normalization, a UNet-based backbone for HBS prediction, and a post-STN for angle regularization. Experiments show that HBSN accurately computes HBS representations, even for complex shapes. Furthermore, we demonstrate how HBSN can be directly incorporated into existing deep learning segmentation models, improving their performance through the use of shape priors. The results confirm the utility of HBSN as a general-purpose module for embedding geometric shape information into computer vision pipelines.