Deep neural networks enriched with structural information have been widely employed for facial expression recognition tasks. However, these methods often depend on hierarchical information rather than face property to finish expression recognition. In this paper, we propose a cross-modal network with strong biological and structural information for facial expression recognition (CMNet). CMNet can respectively learn expression information via face symmetry on a whole face, left and right half faces to extract complementary facial features. To prevent negative effect of biological and structural information fusion, a salient facial information refinement module can obtain salient facial expression information to improve stability of an obtained facial expression classifier. To reduce reliance on unilateral facial features, a half-face alignment optimization mechanism is designed to align obtained expression information of learned left and right half faces. Our experimental results demonstrate that CMNet outperforms several novel methods, i.e., SCN and LAENet-SA for facial expression recognition. Codes can be obtained at https://github.com/hellloxiaotian/CMNet.