The powerful generative capabilities of diffusion models have significantly advanced the field of image synthesis, enhancing both full image generation and inpainting-based image editing. Despite their remarkable advancements, diffusion models also raise concerns about potential misuse for malicious purposes. However, existing approaches struggle to identify images generated by diffusion-based inpainting models, even when similar inpainted images are included in their training data. To address this challenge, we propose a novel detection method based on End-to-end denoising diffusion (End4). Specifically, End4 designs a denoising reconstruction model to improve the alignment degree between the latent spaces of the reconstruction and detection processes, thus reconstructing features that are more conducive to detection. Meanwhile, it leverages a Scale-aware Pyramid-like Fusion Module (SPFM) that refines local image features under the guidance of attention pyramid layers at different scales, enhancing feature discriminability. Additionally, to evaluate detection performance on inpainted images, we establish a comprehensive benchmark comprising images generated from five distinct masked regions. Extensive experiments demonstrate that our End4 effectively generalizes to unseen masking patterns and remains robust under various perturbations. Our code and dataset will be released soon.