We present OvSGTR, a novel transformer-based framework for fully open-vocabulary scene graph generation that overcomes the limitations of traditional closed-set models. Conventional methods restrict both object and relationship recognition to a fixed vocabulary, hindering their applicability to real-world scenarios where novel concepts frequently emerge. In contrast, our approach jointly predicts objects (nodes) and their inter-relationships (edges) beyond predefined categories. OvSGTR leverages a DETR-like architecture featuring a frozen image backbone and text encoder to extract high-quality visual and semantic features, which are then fused via a transformer decoder for end-to-end scene graph prediction. To enrich the model's understanding of complex visual relations, we propose a relation-aware pre-training strategy that synthesizes scene graph annotations in a weakly supervised manner. Specifically, we investigate three pipelines--scene parser-based, LLM-based, and multimodal LLM-based--to generate transferable supervision signals with minimal manual annotation. Furthermore, we address the common issue of catastrophic forgetting in open-vocabulary settings by incorporating a visual-concept retention mechanism coupled with a knowledge distillation strategy, ensuring that the model retains rich semantic cues during fine-tuning. Extensive experiments on the VG150 benchmark demonstrate that OvSGTR achieves state-of-the-art performance across multiple settings, including closed-set, open-vocabulary object detection-based, relation-based, and fully open-vocabulary scenarios. Our results highlight the promise of large-scale relation-aware pre-training and transformer architectures for advancing scene graph generation towards more generalized and reliable visual understanding.