Human-Centric Video Generation (HCVG) methods seek to synthesize human videos from multimodal inputs, including text, image, and audio. Existing methods struggle to effectively coordinate these heterogeneous modalities due to two challenges: the scarcity of training data with paired triplet conditions and the difficulty of collaborating the sub-tasks of subject preservation and audio-visual sync with multimodal inputs. In this work, we present HuMo, a unified HCVG framework for collaborative multimodal control. For the first challenge, we construct a high-quality dataset with diverse and paired text, reference images, and audio. For the second challenge, we propose a two-stage progressive multimodal training paradigm with task-specific strategies. For the subject preservation task, to maintain the prompt following and visual generation abilities of the foundation model, we adopt the minimal-invasive image injection strategy. For the audio-visual sync task, besides the commonly adopted audio cross-attention layer, we propose a focus-by-predicting strategy that implicitly guides the model to associate audio with facial regions. For joint learning of controllabilities across multimodal inputs, building on previously acquired capabilities, we progressively incorporate the audio-visual sync task. During inference, for flexible and fine-grained multimodal control, we design a time-adaptive Classifier-Free Guidance strategy that dynamically adjusts guidance weights across denoising steps. Extensive experimental results demonstrate that HuMo surpasses specialized state-of-the-art methods in sub-tasks, establishing a unified framework for collaborative multimodal-conditioned HCVG. Project Page: https://phantom-video.github.io/HuMo.