Deep learning-based image manipulation localization (IML) methods have achieved remarkable performance in recent years, but typically rely on large-scale pixel-level annotated datasets. To address the challenge of acquiring high-quality annotations, some recent weakly supervised methods utilize image-level labels to segment manipulated regions. However, the performance is still limited due to insufficient supervision signals. In this study, we explore a form of weak supervision that improves the annotation efficiency and detection performance, namely scribble annotation supervision. We re-annotate mainstream IML datasets with scribble labels and propose the first scribble-based IML (Sc-IML) dataset. Additionally, we propose the first scribble-based weakly supervised IML framework. Specifically, we employ self-supervised training with a structural consistency loss to encourage the model to produce consistent predictions under multi-scale and augmented inputs. In addition, we propose a prior-aware feature modulation module (PFMM) that adaptively integrates prior information from both manipulated and authentic regions for dynamic feature adjustment, further enhancing feature discriminability and prediction consistency in complex scenes. We also propose a gated adaptive fusion module (GAFM) that utilizes gating mechanisms to regulate information flow during feature fusion, guiding the model toward emphasizing potential manipulated regions. Finally, we propose a confidence-aware entropy minimization loss (${\mathcal{L}}_{ {CEM }}$). This loss dynamically regularizes predictions in weakly annotated or unlabeled regions based on model uncertainty, effectively suppressing unreliable predictions. Experimental results show that our method outperforms existing fully supervised approaches in terms of average performance both in-distribution and out-of-distribution.