Category-level object pose estimation aims to predict the 6D pose and size of previously unseen instances from predefined categories, requiring strong generalization across diverse object instances. Although many previous methods attempt to mitigate intra-class variations, they often struggle with instances exhibiting complex geometries or significant deviations from canonical shapes. To address this issue, we propose INKL-Pose, a novel category-level object pose estimation framework that enables INstance-adaptive Keypoint Learning with local-to-global geometric aggregation. Specifically, our method first predicts semantically consistent and geometrically informative keypoints using an Instance-Adaptive Keypoint Detector, then refines them: (1) a Local Keypoint Feature Aggregator capturing fine-grained geometries, and (2) a Global Keypoint Feature Aggregator using bidirectional Mamba for structural consistency. To enable bidirectional modeling in Mamba, we introduce a simple yet effective Feature Sequence Flipping strategy that preserves spatial coherence while constructing backward feature sequence. Additionally, we design a surface loss and a separation loss to encourage uniform coverage and spatial diversity in keypoint distribution. The resulting keypoints are mapped to a canonical space for 6D pose and size regression. Extensive experiments on CAMERA25, REAL275, and HouseCat6D show that INKL-Pose achieves state-of-the-art performance with 16.7M parameters and runs at 36 FPS on an NVIDIA RTX 4090D GPU.