Recent advancements in multi-scale architectures have demonstrated exceptional performance in image denoising tasks. However, existing architectures mainly depends on a fixed single-input single-output Unet architecture, ignoring the multi-scale representations of pixel level. In addition, previous methods treat the frequency domain uniformly, ignoring the different characteristics of high-frequency and low-frequency noise. In this paper, we propose a novel multi-scale adaptive dual-domain network (MADNet) for image denoising. We use image pyramid inputs to restore noise-free results from low-resolution images. In order to realize the interaction of high-frequency and low-frequency information, we design an adaptive spatial-frequency learning unit (ASFU), where a learnable mask is used to separate the information into high-frequency and low-frequency components. In the skip connections, we design a global feature fusion block to enhance the features at different scales. Extensive experiments on both synthetic and real noisy image datasets verify the effectiveness of MADNet compared with current state-of-the-art denoising approaches.