Open-World Object Detection (OWOD) enriches traditional object detectors by enabling continual discovery and integration of unknown objects via human guidance. However, existing OWOD approaches frequently suffer from semantic confusion between known and unknown classes, alongside catastrophic forgetting, leading to diminished unknown recall and degraded known-class accuracy. To overcome these challenges, we propose Combinatorial Open-World Detection (CROWD), a unified framework reformulating unknown object discovery and adaptation as an interwoven combinatorial (set-based) data-discovery (CROWD-Discover) and representation learning (CROWD-Learn) task. CROWD-Discover strategically mines unknown instances by maximizing Submodular Conditional Gain (SCG) functions, selecting representative examples distinctly dissimilar from known objects. Subsequently, CROWD-Learn employs novel combinatorial objectives that jointly disentangle known and unknown representations while maintaining discriminative coherence among known classes, thus mitigating confusion and forgetting. Extensive evaluations on OWOD benchmarks illustrate that CROWD achieves improvements of 2.83% and 2.05% in known-class accuracy on M-OWODB and S-OWODB, respectively, and nearly 2.4x unknown recall compared to leading baselines.