Video-based human pose estimation models aim to address scenarios that cannot be effectively solved by static image models such as motion blur, out-of-focus and occlusion. Most existing approaches consist of two stages: detecting human instances in each image frame and then using a temporal model for single-person pose estimation. This approach separates the spatial and temporal dimensions and cannot capture the global spatio-temporal context between spatial instances for end-to-end optimization. In addition, it relies on separate detectors and complex post-processing such as RoI cropping and NMS, which reduces the inference efficiency of the video scene. To address the above problems, we propose VEPE (Video End-to-End Pose Estimation), a simple and flexible framework for end-to-end pose estimation in video. The framework utilizes three crucial spatio-temporal Transformer components: the Spatio-Temporal Pose Encoder (STPE), the Spatio-Temporal Deformable Memory Encoder (STDME), and the Spatio-Temporal Pose Decoder (STPD). These components are designed to effectively utilize temporal context for optimizing human body pose estimation. Furthermore, to reduce the mismatch problem during the cross-frame pose query matching process, we propose an instance consistency mechanism, which aims to enhance the consistency and discrepancy of the cross-frame instance query and realize the instance tracking function, which in turn accurately guides the pose query to perform cross-frame matching. Extensive experiments on the Posetrack dataset show that our approach outperforms most two-stage models and improves inference efficiency by 300%.