Large vision-language models (VLMs) are vulnerable to transfer-based adversarial perturbations, enabling attackers to optimize on surrogate models and manipulate black-box VLM outputs. Prior targeted transfer attacks often overfit surrogate-specific embedding space by relying on a single reference and emphasizing final-layer alignment, which underutilizes intermediate semantics and degrades transfer across heterogeneous VLMs. To address this, we propose SGHA-Attack, a Semantic-Guided Hierarchical Alignment framework that adopts multiple target references and enforces intermediate-layer consistency. Concretely, we generate a visually grounded reference pool by sampling a frozen text-to-image model conditioned on the target prompt, and then carefully select the Top-K most semantically relevant anchors under the surrogate to form a weighted mixture for stable optimization guidance. Building on these anchors, SGHA-Attack injects target semantics throughout the feature hierarchy by aligning intermediate visual representations at both global and spatial granularities across multiple depths, and by synchronizing intermediate visual and textual features in a shared latent subspace to provide early cross-modal supervision before the final projection. Extensive experiments on open-source and commercial black-box VLMs show that SGHA-Attack achieves stronger targeted transferability than prior methods and remains robust under preprocessing and purification defenses.