The rapid advancement of generative AI has enabled the mass production of photorealistic synthetic images, blurring the boundary between authentic and fabricated visual content. This challenge is particularly evident in deepfake scenarios involving facial manipulation, but also extends to broader AI-generated content (AIGC) cases involving fully synthesized scenes. As such content becomes increasingly difficult to distinguish from reality, the integrity of visual media is under threat. To address this issue, we propose a physically interpretable deepfake detection framework and demonstrate that defocus blur can serve as an effective forensic signal. Defocus blur is a depth-dependent optical phenomenon that naturally occurs in camera-captured images due to lens focus and scene geometry. In contrast, synthetic images often lack realistic depth-of-field (DoF) characteristics. To capture these discrepancies, we construct a defocus blur map and use it as a discriminative feature for detecting manipulated content. Unlike RGB textures or frequency-domain signals, defocus blur arises universally from optical imaging principles and encodes physical scene structure. This makes it a robust and generalizable forensic cue. Our approach is supported by three in-depth feature analyses, and experimental results confirm that defocus blur provides a reliable and interpretable cue for identifying synthetic images. We aim for our defocus-based detection pipeline and interpretability tools to contribute meaningfully to ongoing research in media forensics. The implementation is publicly available at: https://github.com/irissun9602/Defocus-Deepfake-Detection