Image restoration~(IR), as a fundamental multimedia data processing task, has a significant impact on downstream visual applications. In recent years, researchers have focused on developing general-purpose IR models capable of handling diverse degradation types, thereby reducing the cost and complexity of model development. Current mainstream approaches are based on three architectural paradigms: CNNs, Transformers, and Mambas. CNNs excel in efficient inference, whereas Transformers and Mamba excel at capturing long-range dependencies and modeling global contexts. While each architecture has demonstrated success in specialized, single-task settings, limited efforts have been made to effectively integrate heterogeneous architectures to jointly address diverse IR challenges. To bridge this gap, we propose RestorMixer, an efficient and general-purpose IR model based on mixed-architecture fusion. RestorMixer adopts a three-stage encoder-decoder structure, where each stage is tailored to the resolution and feature characteristics of the input. In the initial high-resolution stage, CNN-based blocks are employed to rapidly extract shallow local features. In the subsequent stages, we integrate a refined multi-directional scanning Mamba module with a multi-scale window-based self-attention mechanism. This hierarchical and adaptive design enables the model to leverage the strengths of CNNs in local feature extraction, Mamba in global context modeling, and attention mechanisms in dynamic feature refinement. Extensive experimental results demonstrate that RestorMixer achieves leading performance across multiple IR tasks while maintaining high inference efficiency. The official code can be accessed at https://github.com/ClimBin/RestorMixer.