In recent years, diffusion models have demonstrated remarkable potential across diverse domains, from vision generation to language modeling. Transferring its generative capabilities to modern end-to-end autonomous driving systems has also emerged as a promising direction. However, existing diffusion-based trajectory generative models often exhibit mode collapse where different random noises converge to similar trajectories after the denoising process.Therefore, state-of-the-art models often rely on anchored trajectories from pre-defined trajectory vocabulary or scene priors in the training set to mitigate collapse and enrich the diversity of generated trajectories, but such inductive bias are not available in real-world deployment, which can be challenged when generalizing to unseen scenarios. In this work, we investigate the possibility of effectively tackling the mode collapse challenge without the assumption of pre-defined trajectory vocabulary or pre-computed scene priors. Specifically, we propose TransDiffuser, an encoder-decoder based generative trajectory planning model, where the encoded scene information and motion states serve as the multi-modal conditional input of the denoising decoder. Different from existing approaches, we exploit a simple yet effective multi-modal representation decorrelation optimization mechanism during the denoising process to enrich the latent representation space which better guides the downstream generation. Without any predefined trajectory anchors or pre-computed scene priors, TransDiffuser achieves the PDMS of 94.85 on the closed-loop planning-oriented benchmark NAVSIM, surpassing previous state-of-the-art methods. Qualitative evaluation further showcases TransDiffuser generates more diverse and plausible trajectories which explore more drivable area.