Sketch editing requires jointly handling high-level semantic changes and precise local redrawing, a combination that is particularly challenging for sparse, style-sensitive line art. Unlike natural images, sketches rely on minimal visual cues, making it difficult for existing methods to reconcile global semantic modifications with fine-grained structural control while preserving overall coherence. We present SketchAssist, an interactive sketch assistant that unifies instruction-guided editing with line-guided region redrawing, enabling efficient and controllable sketch manipulation while preserving overall composition. To support this task, we introduce a controllable data generation pipeline that constructs structured edit sequences with precise attribute variations and maintains structural alignment across multi-step modifications, while expanding stylistic diversity via style-preserving transformations. Building on this data, SketchAssist adopts a unified framework based on DiT, using a multi-channel input representation to encode sketches, masks, and guidance signals within a single interface. To further handle different editing modes, we integrate a Task-guided Mixture-of-Experts (T-MoE) into LoRA layers, enabling adaptive control over semantic and structural guidance. Extensive experiments demonstrate state-of-the-art performance on both tasks, achieving strong instruction adherence and improved structural and style consistency compared to recent methods. Together, our method provide a practical and controllable solution for sketch editing.