Machine learning, particularly deep learning, is transforming industrial quality inspection. Yet, training robust machine learning models typically requires large volumes of high-quality labeled data, which are expensive, time-consuming, and labor-intensive to obtain in manufacturing. Moreover, defective samples are intrinsically rare, leading to severe class imbalance that degrades model performance. These data constraints hinder the widespread adoption of machine learning-based quality inspection methods in real production environments. Synthetic data generation (SDG) offers a promising solution by enabling the creation of large, balanced, and fully annotated datasets in an efficient, cost-effective, and scalable manner. This paper presents a hybrid SDG framework that integrates simulation-based rendering, domain randomization, and real background compositing to enable zero-shot learning for computer vision-based industrial part inspection without manual annotation. The SDG pipeline generates 12,960 labeled images in one hour by varying part geometry, lighting, and surface properties, and then compositing synthetic parts onto real image backgrounds. A two-stage architecture utilizing a YOLOv8n backbone for object detection and MobileNetV3-small for quality classification is trained exclusively on synthetic data and evaluated on 300 real industrial parts. The proposed approach achieves an mAP@0.5 of 0.995 for detection, 96% classification accuracy, and 90.1% balanced accuracy. Comparative evaluation against few-shot real-data baseline approaches demonstrates significant improvement. The proposed SDG-based approach achieves 90-91% balanced accuracy under severe class imbalance, while the baselines reach only 50% accuracy. These results demonstrate that the proposed method enables annotation-free, scalable, and robust quality inspection for real-world manufacturing applications.