class PySimpleApp(wx.App):

    def __init__(self, redirect=False, filename=None,
                 useBestVisual=False, clearSigInt=True):
        wx.App.__init__(self, redirect, filename, useBestVisual,
                clearSigInt)

    def OnInit(self):
        return True

下面是wx.PySimpleApp一个简单用法：

if __name__ == '__main__':
    app = wx.PySimpleApp()
    frame = MyNewFrame(None)
    frame.Show(True)
    app.MainLoop()