It remains challenging to assess driver fatigue from untrimmed videos under constrained computational budgets, due to the difficulty of modeling long-range temporal dependencies in subtle facial expressions. Some existing approaches rely on computationally heavy architectures, whereas others employ traditional lightweight pairwise graph networks, despite their limited capacity to model high-order synergies and global temporal context. Therefore, we propose HST-HGN, a novel Heterogeneous Spatial-Temporal Hypergraph Network driven by Bidirectional State Space Models. Spatially, we introduce a hierarchical hypergraph network to fuse pose-disentangled geometric topologies with multi-modal texture patches dynamically. This formulation encapsulates high-order synergistic facial deformations, effectively overcoming the limitations of conventional methods. In temporal terms, a Bi-Mamba module with linear complexity is applied to perform bidirectional sequence modeling. This explicit temporal-evolution filtering enables the network to distinguish highly ambiguous transient actions, such as yawning versus speaking, while encompassing their complete physiological lifecycles. Extensive evaluations across diverse fatigue benchmarks demonstrate that HST-HGN achieves state-of-the-art performance. In particular, our method strikes a balance between discriminative power and computational efficiency, making it well-suited for real-time in-cabin edge deployment.