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Policy Split: Incentivizing Dual-Mode Exploration in LLM Reinforcement with Dual-Mode Entropy Regularization METER: Evaluating Multi-Level Contextual Causal Reasoning in Large Language Models Think Before you Write: QA-Guided Reasoning for Character Descriptions in Books METRO: Towards Strategy Induction from Expert Dialogue Transcripts for Non-collaborative Dialogues Retrieval as Generation: A Unified Framework with Self-Triggered Information Planning Do LLMs Know Tool Irrelevance? Demystifying Structural Alignment Bias in Tool Invocations Enhancing Multimodal Large Language Models for Ancient Chinese Character Evolution Analysis via Glyph-Driven Fine-Tuning Exploring Knowledge Conflicts for Faithful LLM Reasoning: Benchmark and Method CocoaBench: Evaluating Unified Digital Agents in the Wild MathAgent: Adversarial Evolution of Constraint Graphs for Mathematical Reasoning Data Synthesis Efficient Training for Cross-lingual Speech Language Models Shared Emotion Geometry Across Small Language Models: A Cross-Architecture Study of Representation, Behavior, and Methodological Confounds A Systematic Analysis of the Impact of Persona Steering on LLM Capabilities Uncertainty-Aware Web-Conditioned Scientific Fact-Checking When Valid Signals Fail: Regime Boundaries Between LLM Features and RL Trading Policies When Verification Fails: How Compositionally Infeasible Claims Escape Rejection Mem$^2$Evolve: Towards Self-Evolving Agents via Co-Evolutionary Capability Expansion and Experience Distillation AOP-Smart: A RAG-Enhanced Large Language Model Framework for Adverse Outcome Pathway Analysis Advancing Polish Language Modeling through Tokenizer Optimization in the Bielik v3 7B and 11B Series TInR: Exploring Tool-Internalized Reasoning in Large Language Models Do BERT Embeddings Encode Narrative Dimensions? A Token-Level Probing Analysis of Time, Space, Causality, and Character in Fiction Generating Multiple-Choice Knowledge Questions with Interpretable Difficulty Estimation using Knowledge Graphs and Large Language Models Deep-Reporter: Deep Research for Grounded Multimodal Long-Form Generation Too Nice to Tell the Truth: Quantifying Agreeableness-Driven Sycophancy in Role-Playing Language Models Learning and Enforcing Context-Sensitive Control for LLMs Efficient Process Reward Modeling via Contrastive Mutual Information Computational Lesions in Multilingual Language Models Separate Shared and Language-specific Brain Alignment Bridging Linguistic Gaps: Cross-Lingual Mapping in Pre-Training and Dataset for Enhanced Multilingual LLM Performance Early Decisions Matter: Proximity Bias and Initial Trajectory Shaping in Non-Autoregressive Diffusion Language Models LLMs Should Incorporate Explicit Mechanisms for Human Empathy
Interpretable Tau-PET Synthesis from Multimodal T1-Weight...
Agamdeep S. Chopra, Caitlin Neher, Tianyi Ren, Juampablo E. Hera · 2026-02-26 · via cs.AI updates on arXiv.org

Tau positron emission tomography (tau-PET) is an important in vivo biomarker of Alzheimer's disease, but its cost, limited availability, and acquisition burden restrict broad clinical use. This work proposes an interpretable multimodal image synthesis framework for generating tau-PET from paired T1-weighted and FLAIR MRI. The proposed model combines a Partial Information Decomposition-inspired vector-quantized encoder, which separates latent representations into redundant, unique, and complementary (synergistic) components, with a Half-UNet decoder that preserves anatomical structure through edge-conditioned pseudo-skip connections rather than direct encoder-to-decoder feature bypass. The method was evaluated on 605 training and 83 validation subjects from ADNI-3 and OASIS-3 and compared against continuous-latent, discrete-latent, and direct-regression baselines, including VAE, VQ-VAE, UNet, and SPADE-based UNet variants. Evaluation included raw PET reconstruction, SUVR reconstruction, high-uptake region preservation, regional agreement, Braak-stage tracking, and post-hoc statistical testing. Across 17 evaluated models, the proposed DQ2H-MSE-Inf variant achieved the best raw PET fidelity and the strongest downstream Braak-stage performance, while remaining competitive on SUVR reconstruction and regional agreement. Shapley analysis further showed that complementary and redundant latent components contributed the largest gains, supporting the role of cross-modal interaction in tau-PET recovery. We show that our method can support clinically relevant tau-PET synthesis while providing improved architectural interpretability.