Cascaded speech-to-text translation (S2TT) systems for low-resource languages can suffer from structural noise, particularly the loss of punctuation during the Automatic Speech Recognition (ASR) phase. This research investigates the impact of such noise on Nepali-to-English translation and proposes an optimized pipeline to mitigate quality degradation. We first establish highly proficient ASR and NMT components: a Wav2Vec2-XLS-R-300m model achieved a state-of-the-art 2.72% CER on OpenSLR-54, and a multi-stage fine-tuned MarianMT model reached a 28.32 BLEU score on the FLORES-200 benchmark. We empirically investigate the influence of punctuation loss, demonstrating that unpunctuated ASR output significantly degrades translation quality, causing a massive 20.7% relative BLEU drop on the FLORES benchmark. To overcome this, we propose and evaluate an intermediate Punctuation Restoration Module (PRM). The final S2TT pipeline was tested across three configurations on a custom dataset. The optimal configuration, which applied the PRM directly to ASR output, achieved a 4.90 BLEU point gain over the direct ASR-to-NMT baseline (BLEU 36.38 vs. 31.48). This improvement was validated by human assessment, which confirmed the optimized pipeline's superior Adequacy (3.673) and Fluency (3.804) with inter-rater reliability (Krippendorff's $α {\geq}$ 0.723). This work validates that targeted punctuation restoration is the most effective intervention for mitigating structural noise in the Nepali S2TT pipeline. It establishes an optimized baseline and demonstrates a critical architectural insight for developing cascaded speech translation systems for similar low-resource languages.