Large Language Models (LLMs) based on Mixture-of-Experts (MoE) are pivotal in industrial applications for their ability to scale performance efficiently. However, standard MoEs enforce uniform expert sizes,creating a rigidity that fails to align computational costs with varying token-level complexity. While heterogeneous expert architectures attempt to address this by diversifying expert sizes, they often suffer from significant system-level challenges, specifically unbalanced GPU utilization and inefficient parameter utilization, which hinder practical deployment. To bridge the gap between theoretical heterogeneity and robust industrial application, we propose Mixture of Heterogeneous Grouped Experts (MoHGE) which introduces a two-level routing mechanism to enable flexible, resource-aware expert combinations. To optimize inference efficiency, we propose a Group-Wise Auxiliary Loss, which dynamically steers tokens to the most parameter-efficient expert groups based on task difficulty. To address the critical deployment challenge of GPU load balancing, we introduce an All-size Group-decoupling Allocation strategy coupled with an Intra-Group Experts Auxiliary Loss. These mechanisms collectively ensure uniform computation distribution across GPUs. Extensive evaluations demonstrate that MoHGE matches the performance of MoE architectures while reducing the total parameters by approximately 20% and maintaining balanced GPU utilization. Our work establishes a scalable paradigm for resource-efficient MoE design, offering a practical solution for optimizing inference costs in real-world scenarios. The code is publicly available at https://github.com/UnicomAI/MoHGE.