Safety alignment is critical for LLM-powered systems. While recent LLM-powered guardrail approaches such as LlamaGuard achieve high detection accuracy of unsafe inputs written in English (e.g., ``How to create a bomb?''), they struggle with multilingual unsafe inputs. This limitation leaves LLM systems vulnerable to unsafe and jailbreak prompts written in low-resource languages such as those in Southeast Asia. This paper introduces SEALGuard, a multilingual guardrail designed to improve the safety alignment across diverse languages. It aims to address the multilingual safety alignment gap of existing guardrails and ensure effective filtering of unsafe and jailbreak prompts in LLM-powered systems. We adapt a general-purpose multilingual language model into a multilingual guardrail using low-rank adaptation (LoRA). We construct SEALSBench, a large-scale multilingual safety alignment dataset containing over 260,000 prompts in ten languages, including safe, unsafe, and jailbreak cases. We evaluate SEALGuard against state-of-the-art guardrails such as LlamaGuard on this benchmark. Our findings show that multilingual unsafe and jailbreak prompts substantially degrade the performance of the state-of-the-art LlamaGuard, which experiences a drop in Defense Success Rate (DSR) by 9% and 18%, respectively, compared to its performance on English-only prompts. In contrast, SEALGuard outperforms existing guardrails in detecting multilingual unsafe and jailbreak prompts, improving DSR by 48% over LlamaGuard and achieving the best DSR, precision, and F1-score. Our ablation study further reveals the contributions of adaptation strategies and model size to the overall performance of SEALGuard. We release our pre-trained model and benchmark at https://github.com/awsm-research/SEALGuard to support further research.