With the rapid adoption of multimodal large language models (MLLMs) across diverse applications, there is a pressing need for task-centered, high-quality training data. A key limitation of current training datasets is their reliance on sparse annotations mined from the Internet or entered via manual typing that capture only a fraction of an image's visual content. Dense annotations are more valuable but remain scarce. Traditional text-based annotation pipelines are poorly suited for creating dense annotations: typing limits expressiveness, slows annotation speed, and underrepresents nuanced visual features, especially in specialized areas such as multicultural imagery and 3D asset annotation. In this paper, we present DenseAnnotate, an audio-driven online annotation platform that enables efficient creation of dense, fine-grained annotations for images and 3D assets. Annotators narrate observations aloud while synchronously linking spoken phrases to image regions or 3D scene parts. Our platform incorporates speech-to-text transcription and region-of-attention marking. To demonstrate the effectiveness of DenseAnnotate, we conducted case studies involving over 1,000 annotators across two domains: culturally diverse images and 3D scenes. We curate a human-annotated multi-modal dataset of 3,531 images, 898 3D scenes, and 7,460 3D objects, with audio-aligned dense annotations in 20 languages, including 8,746 image captions, 2,000 scene captions, and 19,000 object captions. Models trained on this dataset exhibit improvements of 5% in multilingual, 47% in cultural alignment, and 54% in 3D spatial capabilities. Our results show that our platform offers a feasible approach for future vision-language research and can be applied to various tasks and diverse types of data.