Large Language Models (LLMs) have demonstrated remarkable capabilities in various tasks. However, they remain exposed to jailbreak attacks, eliciting harmful responses. The nested scenario strategy has been increasingly adopted across various methods, demonstrating immense potential. Nevertheless, these methods are easily detectable due to their prominent malicious intentions. In this work, we are the first to find and systematically verify that LLMs' alignment defenses are not sensitive to nested scenarios, where these scenarios are highly semantically relevant to the queries and incorporate targeted toxic knowledge. This is a crucial yet insufficiently explored direction. Based on this, we propose RTS-Attack (Semantically Relevant Nested Scenarios with Targeted Toxic Knowledge), an adaptive and automated framework to examine LLMs' alignment. By building scenarios highly relevant to the queries and integrating targeted toxic knowledge, RTS-Attack bypasses the alignment defenses of LLMs. Moreover, the jailbreak prompts generated by RTS-Attack are free from harmful queries, leading to outstanding concealment. Extensive experiments demonstrate that RTS-Attack exhibits superior performance in both efficiency and universality compared to the baselines across diverse advanced LLMs, including GPT-4o, Llama3-70b, and Gemini-pro. Our complete code is available at https://github.com/nercode/Work. WARNING: THIS PAPER CONTAINS POTENTIALLY HARMFUL CONTENT.