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Playing Along: Learning a Double-Agent Defender for Belief Steering via Theory of Mind RPA-Check: A Multi-Stage Automated Framework for Evaluating Dynamic LLM-based Role-Playing Agents A Triadic Suffix Tokenization Scheme for Numerical Reasoning Hidden Measurement Error in LLM Pipelines Distorts Annotation, Evaluation, and Benchmarking Synthius-Mem: Brain-Inspired Hallucination-Resistant Persona Memory Achieving 94.4% Memory Accuracy and 99.6% Adversarial Robustness on LoCoMo Time is Not a Label: Continuous Phase Rotation for Temporal Knowledge Graphs and Agentic Memory NovBench: Evaluating Large Language Models on Academic Paper Novelty Assessment Policy Split: Incentivizing Dual-Mode Exploration in LLM Reinforcement with Dual-Mode Entropy Regularization METER: Evaluating Multi-Level Contextual Causal Reasoning in Large Language Models Think Before you Write: QA-Guided Reasoning for Character Descriptions in Books METRO: Towards Strategy Induction from Expert Dialogue Transcripts for Non-collaborative Dialogues Retrieval as Generation: A Unified Framework with Self-Triggered Information Planning Do LLMs Know Tool Irrelevance? Demystifying Structural Alignment Bias in Tool Invocations Enhancing Multimodal Large Language Models for Ancient Chinese Character Evolution Analysis via Glyph-Driven Fine-Tuning Polyglot Teachers: Evaluating Language Models for Multilingual Synthetic Data Generation Exploring Knowledge Conflicts for Faithful LLM Reasoning: Benchmark and Method CocoaBench: Evaluating Unified Digital Agents in the Wild MathAgent: Adversarial Evolution of Constraint Graphs for Mathematical Reasoning Data Synthesis Evaluating Memory Capability in Continuous Lifelog Scenario How Robust Are Large Language Models for Clinical Numeracy? An Empirical Study on Numerical Reasoning Abilities in Clinical Contexts Efficient Training for Cross-lingual Speech Language Models Shared Emotion Geometry Across Small Language Models: A Cross-Architecture Study of Representation, Behavior, and Methodological Confounds A Systematic Analysis of the Impact of Persona Steering on LLM Capabilities Uncertainty-Aware Web-Conditioned Scientific Fact-Checking When Valid Signals Fail: Regime Boundaries Between LLM Features and RL Trading Policies When Verification Fails: How Compositionally Infeasible Claims Escape Rejection Mem$^2$Evolve: Towards Self-Evolving Agents via Co-Evolutionary Capability Expansion and Experience Distillation AOP-Smart: A RAG-Enhanced Large Language Model Framework for Adverse Outcome Pathway Analysis OccuBench: Evaluating AI Agents on Real-World Professional Tasks via Language Environment Simulation Advancing Polish Language Modeling through Tokenizer Optimization in the Bielik v3 7B and 11B Series
Generation of Synthetic Clinical Text: A Systematic Review
Basel Alshaikhdeeb, Ahmed Abdelmonem Hemedan, Soumyabrata Ghosh, · 2025-07-24 · via cs.CL updates on arXiv.org

Generating clinical synthetic text represents an effective solution for common clinical NLP issues like sparsity and privacy. This paper aims to conduct a systematic review on generating synthetic medical free-text by formulating quantitative analysis to three research questions concerning (i) the purpose of generation, (ii) the techniques, and (iii) the evaluation methods. We searched PubMed, ScienceDirect, Web of Science, Scopus, IEEE, Google Scholar, and arXiv databases for publications associated with generating synthetic medical unstructured free-text. We have identified 94 relevant articles out of 1,398 collected ones. A great deal of attention has been given to the generation of synthetic medical text from 2018 onwards, where the main purpose of such a generation is towards text augmentation, assistive writing, corpus building, privacy-preserving, annotation, and usefulness. Transformer architectures were the main predominant technique used to generate the text, especially the GPTs. On the other hand, there were four main aspects of evaluation, including similarity, privacy, structure, and utility, where utility was the most frequent method used to assess the generated synthetic medical text. Although the generated synthetic medical text demonstrated a moderate possibility to act as real medical documents in different downstream NLP tasks, it has proven to be a great asset as augmented, complementary to the real documents, towards improving the accuracy and overcoming sparsity/undersampling issues. Yet, privacy is still a major issue behind generating synthetic medical text, where more human assessments are needed to check for the existence of any sensitive information. Despite that, advances in generating synthetic medical text will considerably accelerate the adoption of workflows and pipeline development, discarding the time-consuming legalities of data transfer.