Multimodal large language models (MLLMs) have shown remarkable capabilities in multimodal perception and understanding tasks. However, their effectiveness in specialized domains, such as remote sensing and medical imaging, remains limited. A natural approach to domain adaptation is to inject domain knowledge through textual instructions, prompts, or auxiliary captions. Surprisingly, we find that such input-level domain knowledge injection yields little to no improvement on scientific multimodal tasks, even when the domain knowledge is explicitly provided. This observation suggests that current MLLMs fail to internalize domain-specific priors through language alone, and that domain knowledge must be integrated at the optimization level. Motivated by this insight, we propose a reinforcement fine-tuning framework that incorporates domain knowledge directly into the learning objective. Instead of treating domain knowledge as descriptive information, we encode it as domain-informed constraints and reward signals, shaping the model's behavior in the output space. Extensive experiments across multiple datasets in remote sensing and medical domains consistently demonstrate good performance gains, achieving state-of-the-art results on multimodal domain tasks. Our results highlight the necessity of optimization-level domain knowledge integration and reveal a fundamental limitation of textual domain conditioning in current MLLMs.