Authorities in Colorado are desperately searching for a pair of siblings who mysteriously disappeared from their house in the middle of the night.

Eliyah Parras, 15, and Naomie Parras, 12, were last seen in the area of 37th Street and 23rd Avenue in the city of Evans after leaving their home in the 2300 block of Mission Springs Way at 3am.

They have not been seen or heard from since, despite police reporting they have received 'numerous tips from the public.'

'This has been an incredibly difficult time for the family, who are desperate to bring their loved ones home safely,' the Evans Police Department posted on social media on Sunday.

'We ask our community to keep them in your thoughts and continue sharing information that may help reunite this family.'

The police department also said it wanted 'to emphasize that Eliyah and Naomie are not in trouble.

'Our primary goal is to locate them and bring them home safely as soon as possible.'

Eliyah is described as being approximately six-foot tall with red hair and blue eyes, with an eyebrow piercing.

Naomie similarly has red hair and blue eyes, and has a nose piercing.

Anyone with information on the siblings' whereabouts is urged to call Weld County Dispatch at (970) 356 - 1212 or simply dial 911.