Cleveland Guardians at Seattle Mariners, 7:20 p.m. ET

• Guardians +1.5
• Slade Cecconi Over 4.5 Strikeouts
• Jose Ramirez To Record 2+ Hits + Runs + RBI

Same-Game Parlay Odds: +335 on FanDuel Sportsbook

The Guardians have gotten the best of the Mariners in two of the first three games of the season-opening series, with Cleveland’s latest success coming in the form of a Saturday night 6-5, 10-inning victory. Stephen Vogt’s crew also recorded a 6-4 win Opening Day, so the Guardians bats have been in reasonably good form early even when factoring in Friday’s 5-1 loss.

Cleveland had a +12.0-run differential on the road last season, per Team Rankings, as well as a stellar 42-17 record against the run line as an away underdog in 2025. As such, we’ll start the first leg of our three-leg parlay with a bet on the Guardians keeping any loss to one run or less, while the possibility of an upset victory is very much in play thanks partly to what I see as a starting pitcher advantage for the visitors.

Guardians starter Slade Cecconi was at his best on the road last season, posting a 5-3 record, 3.75 ERA, 1.16 WHIP, 9.2 K/9 and minuscule 1.9 BB/9 across 62.1 innings, per RotoWire. Cecconi has only faced the Mariners once in his career, but that outing went well. The right-hander neutralized Seattle for six innings early in the 2024 season at T-Mobile Park, allowing just one run on three hits and a walk while recording eight strikeouts.

With the Mariners already having gone down on strikes a whopping 36 times in the first three games, a bet on Cecconi getting to at least five Ks – like he did on 10 occasions last season, including seven times on the road – is our second leg.

Meanwhile, the Mariners will hand the ball to Emerson Hancock for Sunday’s series finale, and the talented but inconsistent right-hander will look to start building on last season’s 4-5 record, 4.90 ERA and 1.38 WHIP across 90 innings over 22 appearances (16 starts). Hancock had a rocky body of work at home, where he pitched to a 2-3 mark, 4.98 ERA, 1.29 WHIP, 3.3 BB/9 and 1.2 HR/9 over a 43.1-inning sample.

Hancock did have one of the best starts of his career against Cleveland, however, shutting the Guardians out over seven innings on two hits and a walk on June 15 in Seattle. However, he struggled with left-handed hitters throughout the 2025 campaign, surrendering a .264 average, .844 OPS, .364 wOBA, 5.04 xFIP and 2.3 HR/9 to that handedness, per Fangraphs.

Therefore, our third leg banks on the switch-hitting Jose Ramirez, who’s off to a somewhat slow start but posted an .849 OPS and .354 wOBA against right-handed pitchers last season, potentially recording his first multi-hit game of the season. That possibility is further fueled by Ramirez’s performance against the three pitches Hancock threw most often to left-handed hitters last season, the four-seamer, sinker and changeup (as per Baseball Savant) – the veteran slugger generated respective. 383, .387 and .405 wOBAs against those offerings in 2025, per Fangraphs.